Synthetic mammalian transgene negative autoregulation
نویسندگان
چکیده
منابع مشابه
Synthetic mammalian transgene negative autoregulation
Biological networks contain overrepresented small-scale topologies, typically called motifs. A frequently appearing motif is the transcriptional negative-feedback loop, where a gene product represses its own transcription. Here, using synthetic circuits stably integrated in human kidney cells, we study the effect of negative-feedback regulation on cell-wide (extrinsic) and gene-specific (intrin...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2013
ISSN: 1744-4292,1744-4292
DOI: 10.1038/msb.2013.27